13:07 (IST) 15 Jul 2019 facebook twitter whatsapp Union Home Minister Amit Shah said that the Narendra Modi-led government will never misuse the National Investigation Agency (NIA) law, but in turn, use it to finish off terrorism in the country.The Lower House also witnessed a heated discussion between the Home Minister and AIMIM chief Asaduddin Owaisi over the NIA (Amendment) Bill. The spat started when several opposition leaders, including Owaisi, started interrupting BJP’s Satyapal Singh in the middle of his speech. Singh alleged that the then Hyderabad Police Commissioner was threatened to be transferred if he did not change the course of the investigation of a particular case.Opposing his claim, Owaisi demanded that Singh should place all records related to his claim in the House. On this, the Home Minister got up from his seat and said that the treasury members did not disturb opposition members during their speeches so they should also do the same.Live BlogMonsoon session of Parliament resumed on Monday. Get latest updates here. 12:16 (IST) 15 Jul 2019 If you want good service, you have to pay: Nitin Gadkari on toll collection 13:01 (IST) 15 Jul 2019 16:05 (IST) 15 Jul 2019 Bengal chief secy asked to convene meeting of committee monitoring central schemes Lok Sabha Speaker Om Birla today said that he has asked the chief secretary of West Bengal to convene a meeting of a committee which monitors implementation of central schemes in states. Adhir Ranjan Chowdhury had recently complained that District Development Coordination and Monitoring Committee, also called Disha committee was not meeting regularly. The Speaker was responding to Chowdhury’s complaint. facebook twitter whatsapp Lok Sabha adjourned till tomorrow Lok Sabha has been adjourned for the day, will commence tomorrow at 11 am. facebook twitter whatsapp 12:01 (IST) 15 Jul 2019 ‘Will fight terrorism with zero tolerance’ While introducing the bill, Reddy said special court judges will continue to be appointed by the Chief Justice in order to fast-track the trial processes. He added that state governments must constitute special courts to tackle terrorism. “We will continue to fight terrorism with zero tolerance,” he said. facebook twitter whatsapp Proceedings resume in Rajya Sabha Proceedings have resumed in Rajya Sabha. 18:33 (IST) 15 Jul 2019 Home Minister Amit Shah said that the Narendra Modi-led government will never misuse the National Investigation Agency (NIA) law. (PTI)Parliament Session 2019 Highlights: The Lok Sabha on Monday passed The National Investigation Agency (Amendment) Bill, 2019 which gives powers to the NIA to probe terror attacks targeting Indians and Indian interests abroad. facebook twitter whatsapp Congress gives Adjournment Motion Notice in Lok Sabha The Congress has given notice over the pension of disabled Army personnel. Adhir Ranjan Chowdhury opposes Motor Vehicles Bill Congress leader in Lok Sabha, Adhir Ranjan Chowdhury, also opposed the Motor Vehicles Bill, mainly clauses 33 and 17. However, he acknowledges that it has been overdue. 12:46 (IST) 15 Jul 2019 22:30 (IST) 15 Jul 2019 22:34 (IST) 15 Jul 2019 Rajya Sabha: Jairam Ramesh opposes construction of mega port complex in Chennai Congress’ Jairman Ramesh, while speaking in Rajya Sabha, asked the Environment and Forest Ministry to reject clearance to building of a mega port complex in North Chennai which, he said, poses danger to the fragile ecosystem in the region and livelihood of thousands of fishermen. 17:29 (IST) 15 Jul 2019 Neeraj Shekhar resigns from Rajya Sabha Samajwadi Party leader Neeraj Shekhar, son of former Prime Minister Chandrashekhar, resigns from Rajya Sabha. His resignation has been accepted by Chairman M Venkaiah Naidu.Samajwadi MP Neeraj Shekhar has resigned from RS. His resignation has been accepted by chairman @MVenkaiahNaidu @IndianExpress— abantika ghosh (@abantika77) July 15, 2019 facebook twitter whatsapp TMC MP Saugata Roy gives Adjournment Motion Notice in Lok Sabha Trinamool Congress MP Saugata Roy moved an Adjournment Motion in connection with the Kolkata metro incident in which a senior citizen was killed after his hand got stuck between the train doors. Lok Sabha passes NIA (Amendment) Bill Lok Sabha passes The National Investigation Agency (Amendment) Bill, 2019, giving powers to the NIA to probe terror attacks targeting Indians and Indian interests abroad. 13:04 (IST) 15 Jul 2019 facebook twitter whatsapp Rajya Sabha MPs want discussion on inter-linking of rivers Satyanarayan Jatiya (BJP) raised the issue of inter-linking of rivers to solve the problem of drought. A K Selvaraj (AIADMK) raised similar demand. facebook twitter whatsapp Lok Sabha discusses Demands for Grants under Ministry of Road Transport and Highways’s control Lok Sabha discusses the Demands for Grants under the control of the Ministry of Road Transport and Highways for 2019-20. 16:27 (IST) 15 Jul 2019 facebook twitter whatsapp facebook twitter whatsapp Lok Sabha discusses The National Investigation Agency (Amendment) Bill, 2019 The discussion on The National Investigation Agency (Amendment) Bill, 2019, started in the Lok Sabha. MoS G Kishan Reddy said that the bill is brought in the national interest to broaden the investigating powers of the NIA as part of its zero tolerance policy against terrorism. Meanwhile, Congress leader Manish Tewari accused the government of trying to turn India into a “police state.” 13:47 (IST) 15 Jul 2019 ‘Loot by airlines’: CPM on price hike in airfares CPM’s K K Ragesh demanded roll back in steep hike in airfares in the Kerala-Gulf sector which, he said, was a “loot” by airlines by exploiting migrant workers. While the Calicut-Dubai flight costs Rs 6,000, a Dubai to Calicut flight costs Rs 40,000, he said, adding airfares are jacked up during festive seasons and holidays when migrant workers seek to return to their hometown. facebook twitter whatsapp 13:26 (IST) 15 Jul 2019 14:07 (IST) 15 Jul 2019 14:10 (IST) 15 Jul 2019 facebook twitter whatsapp facebook twitter whatsapp Rajya Sabha adjourned for the day Rajya Sabha has been adjourned for the day, will commence tomorrow at 11am. facebook twitter whatsapp 14:02 (IST) 15 Jul 2019 16:07 (IST) 15 Jul 2019 TMC’s Mahua Moitra opposes Motor Vehicles Bill In Lok Sabha, TMC’s Mahua Moitra opposes the Motors Vehicle Bill on grounds that it provides the public an extension period from a month to a year upon the expiry of driving license, thereby raising questions over one’s safety. facebook twitter whatsapp Rajya Sabha: Vijayasai Reddy speaks on fishermen languishing in Pakistan jail Raising the issue of fishermen languishing in Pakistan jails, V Vijayasai Reddy (YSR-Congress), in Rajya Sabha, said 46 fishermen were captured by Pakistan maritime security agency in October-November last year after illegally entering into Indian waters. According to Pakistan, as many as 483 fishermen are languishing in its jails, he said, adding 22 out of the 46 fishermen captured in October/November 2018 were from Andhra Pradesh who had gone to Gujarat for working on fishing trawlers. “What was the Indian Coast Guard doing when Pakistan intruded into Indian waters,” he asked. He said when the issue was first raised, the then External Affairs Minister Sushma Swaraj had promised to get consular access. “But neither the fishermen were released nor consular access given to families,” he said, asking the Government to urgently intervene to get families consular access. 12:08 (IST) 15 Jul 2019 Rajya Sabha BJP member suggests one nation, one electricity tariff Earlier in the day, BJP Rajya Sabha member Swait Malik suggested uniform electricity tariffs across the country to ensure affordable power for all. Raising the issue during the Zero Hour in the House, he highlighted that power tariffs varies across states. He said while one has to pay Rs 8 per unit of electricity in Punjab, consumers in neighbouring states of Himachal Pradesh and Jammu and Kashmir were paying much less. Malik said because of high power tariff, poor people in Punjab are forced to switch off appliances like fan to save money. He also said that industrial units were migrating from the state due to high cost of power. The BJP member said like GST, one nation one tax, there should be ‘one nation, one electricity tariff’. Assam Congress MPs protest against flood situation outside Parliament Assam Congress MPs today staged a protest in front of the Gandhi statue in Parliament over the flood situation in the state and demanded that the flood situation be declared a national problem.Delhi: Assam Congress MPs protest in front of Gandhi statue in Parliament over flood situation in the state and demand Assam floods to be declared a National Problem pic.twitter.com/FYZTQSfUMx— ANI (@ANI) July 15, 2019 10 Comment(s) 12:53 (IST) 15 Jul 2019 facebook twitter whatsapp facebook twitter whatsapp 13:19 (IST) 15 Jul 2019 ‘Terrorism not a political issue’: BJP’s Satya Pal Singh MP from Baghpat in UP, Satya Pal Singh, said, “Terrorism is a serious crime against humanity. It cannot be treated as a political issue. When we discuss terrorism and laws to tackle it, we should be totally apolitical.” facebook twitter whatsapp 12:00 (IST) 15 Jul 2019 12:33 (IST) 15 Jul 2019 12:58 (IST) 15 Jul 2019 13:05 (IST) 15 Jul 2019 17:42 (IST) 15 Jul 2019 facebook twitter whatsapp Discussion on working of Ministry of Ayurveda underway in RS A discussion on the working of Ministry of Ayurveda, Yoga and Naturopathy, Unani, Sidhha, and Homeopathy (Ayush) underway in the Rajya Sabha. Lok Sabha passes bill to strengthen NIA The Lok Sabha on Monday passed the National Investigation Agency (Amendment) Bill, 2019, which will empower the agency to probe terror attacks targeting Indians and Indian interests on foreign soil. During a discussion on the NIA (Amendment) Bill, 2019, Union Home Minister Amit Shah countered opposition claims over “misuse” of the NIA law. He asserted that the Narendra Modi-led government will never misuse it on the basis of religion and said instead it will ensure the menace of terrorism is uprooted irrespective of the religion of the guilty. Read more Heavy rains outside the Parliament Heavy rains lashed the Parliament premises on Monday eveningWATCH | Heavy rains lash Delhi, bring respite from hot weather conditions pic.twitter.com/AiVJoBSTsb— The Indian Express (@IndianExpress) July 15, 2019 facebook twitter whatsapp 17:52 (IST) 15 Jul 2019 facebook twitter whatsapp facebook twitter whatsapp facebook twitter whatsapp By Express Web Desk |New Delhi | Updated: July 15, 2019 10:37:42 pm 14:03 (IST) 15 Jul 2019 facebook twitter whatsapp Assam floods: Congress MP gives Zero Hour notice in Rajya Sabha Congress MP and Assam Congress Committee President Ripun Bora gave a Zero Hour notice in Rajya Sabha over the flood situation in the north-eastern state.Congress MP and Assam Congress Committee President Ripun Bora has given Zero Hour Notice in Rajya Sabha over flood situation in Assam. pic.twitter.com/SUzMFfQuiq— ANI (@ANI) July 15, 2019 facebook twitter whatsapp facebook twitter whatsapp facebook twitter whatsapp 12:40 (IST) 15 Jul 2019 facebook twitter whatsapp 11:56 (IST) 15 Jul 2019 15:19 (IST) 15 Jul 2019 facebook twitter whatsapp Congress raises questions over validity of NIA Act Opposing the Bill, Congress’ Manish Tewari told those gathered in the Lok Sabha, “The NIA Bill, in 2008, came under specific circumstances after the country felt some unprecedented incidents. The constitutional validity of the NIA Act is not settled as of now. The Bombay High Court had upheld the constitutional validity of the act. The J&K court has not yet given its approval. In November 2013, a division bench of Gauhati High Court had spoken of the ‘illegal organisation’.” Parliament resumes after two-day break Both Houses of Parliament resumed on Monday. After failing to get it through Rajya Sabha in the previous term, the Narendra Modi-government is slated to introduce the Motor Vehicles (Amendment) Bill, 2019, in Lok Sabha on Monday. The Bill, which will be introduced by Union Minister Nitin Gadkari, proposes stricter punishment for traffic violations, simplify vehicle registration process, and overhaul the traffic and transport regulatory framework in India with a view to minimise road accidents. Follow this space for all the latest updates. ‘Why is Bengal govt targetted’: TMC MP Sudipto Sen in Lok Sabha Addressing the Lok Sabha, TMC MP Sudipto Sen said, “Why is Bengal government getting targetted? Why is the central government sending its advisories to Bengal?” facebook twitter whatsapp Related News Rajnath Singh speaks in Rajya Sabha Union Defence Minister Rajnath Singh is addressing the Upper House. National Investigation Agency Amendment Bill tabled in Lok Sabha National Investigation Agency Amendment Bill was introduced by Home Minister (MoS) G Kishan Reddy in Lok Sabha. “This Bill is for the security of the country,” he said. facebook twitter whatsapp Demand to raise royalty on coal in Rajya Sabha Demands to raise royalty on coal, roll back of steep hike in airfares between Kerala and Gulf region and government intervention to help release fishermen captured by Pakistan were among issues raised during the Zero Hour in Rajya Sabha today. BJD’s Amar Patnaik said the rate of royalty paid to state governments on coal produced in states was last changed in April 2012 and as per rule was due to be revised in April 2015 but was not done. facebook twitter whatsapp Advertising TMC’s Shanta Chhetri raises Kolkata metro incident in Rajya Sabha Addressing the Upper House, TMC’s Shanta Chhetri raised the issue of death of a person after his hand got stuck between two sliding doors of the Kolkata Metro on Saturday last. She alleged passenger safety was being compromised with by the Railway Ministry and demanded immediate allocation of funds for proper maintenance and upgrade of the metro rail. 12:28 (IST) 15 Jul 2019 13:34 (IST) 15 Jul 2019 12:05 (IST) 15 Jul 2019 Rain lashes Parliament premises Heavy rain lashed the Parliament premisesExpress photo by Renuka Puri facebook twitter whatsapp Govt can’t do away with tolls, pay for good services: Nitin Gadkari Congress raises issue of illegal mining in Rajya Sabha In his Zero Hour mention, Congress’ P Bhattacharya talked about illegal coal mining in the country and demanded a CBI inquiry to find out people behind such activities. He said many labourers work in illegal mines and they do not even get compensation. Rajya Sabha adjourned till 2 pm Rajya Sabha was adjourned till 2 pm after the Question Hour was over. facebook twitter whatsapp Explained: What the government intends to do to improve road safety?
Source:https://www.aacr.org/ Reviewed by Alina Shrourou, B.Sc. (Editor)Sep 30 2018A phase I clinical trial investigating the use of bacterial Clostridium novyi-NT spores as an injectable monotherapy had manageable toxicities and showed early clinical efficacy in patients with treatment-refractory solid tumor malignancies, according to data presented at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 30-Oct. 3.”Even after a single injection of this bacterial therapy, we see biological and, in some patients, clinically meaningful activity,” said Filip Janku, MD, PhD, associate professor at the Department of Investigational Cancer Therapeutics (Phase I Clinical Trial Program), The University of Texas MD Anderson Cancer Center, Houston. “This strategy is feasible, has manageable adverse effects, and could be clinically meaningful in patients with few therapeutic options.”While prior anticancer therapies have utilized bacteria, these treatments can cause infection and severe side effects, explained Janku. C. novyi-NT is an attenuated bacterium that requires a hypoxic environment, a feature of cancerous lesions, to survive and proliferate and therefore does not affect healthy cells, he noted. “By exploiting the inherent differences between healthy and cancerous tissue, C. novyi-NT represents a very precise anticancer therapeutic that can specifically attack a patient’s cancer,” Janku said.Janku and colleagues evaluated the intratumoral injection of C. novyi-NT spores in an open-label, first-in-human study. Between November 2013 and April 2017, the researchers enrolled 24 patients with treatment-refractory solid tumors, with 15 patients having sarcoma, seven patients having diverse carcinoma, and two patients having melanoma.Tumors were injected with a single dose of C. novyi-NT ranging from 10,000 to 3 million spores. Two patients treated with 3 million spores displayed dose-limiting toxicities of grade 4 sepsis and/or grade 4 gas gangrene; the maximum tolerated dose was therefore determined to be 1 million spores.Of the 22 evaluable patients, 21 had stable disease as measured by RECIST for the injected lesion, with tumor shrinkage of greater than 10 percent observed in 23 percent of patients. When both injected and uninjected lesions were included, the stable disease rate was 86 percent.Related StoriesManuka honey could be useful in treating cystic fibrosis lung infectionAI-enabled device detects if targeted chemotherapy is workingNovel vaccine against bee sting allergy successfully testedJanku noted that RECIST criteria may not accurately capture the results of this trial. “When we inject the tumor, the cells within it die and become necrotic while the remaining tissue becomes inflamed, making the lesion larger in size than the original tumor. Because of this, evaluation via RECIST does not accurately reflect the reduction in tumor burden in these patients.”Janku and colleagues also evaluated the germination of the bacterial spores through clinical and radiological methods. Of the 24 patients enrolled in the trial, tumors from 46 percent displayed spore germination and resultant tumor cell lysis.”Despite the absence of clinical signs of germination in some patients, we saw improved tumor-specific immune responses through the increased secretion of T-cell cytokines and increased presence of tumor infiltrating lymphocytes in injected tumors,” noted Janku. “From these preliminary results, it appears that C. novyi-NT is able to activate the immune response besides causing tumor destruction.”Because C. novyi-NT elicits an innate immune response, Janku believes that this therapy will be synergistic with checkpoint inhibition. The results from this study have led to the initiation of a phase I clinical trial investigating the combination of C. novyi-NT with pembrolizumab (Keytruda).”We were extremely encouraged by the results of this trial, especially in patients with advanced sarcomas, where immunotherapy hasn’t proven very efficacious,” Janku said. “This bacteriolytic strategy has the potential to be clinically meaningful, especially in combination with checkpoint inhibitors, for patients with advanced solid tumors.”Limitations of this study include a short follow-up time for some patients, as many entered into other clinical trials if they became available.